Overdose inowedzera njodzi yekuchengetwa kwemvura uye hyponatremia.Kutungamirirwa kwe hyponatremia kunosiyana pamunhu nemunhu.Muvarwere vane non-symptomatic hyponatremia, desmopressin inofanira kuregwa uye kudziviswa kudyiwa kwemvura.Mune varwere vane symptomatic hyponatremia, zvinokurudzirwa kuwedzera isotonic kana hypertonic sodium chloride kune inodonha.Muzviitiko zvekuchengetwa kwemvura zvakanyanya (macramps uye kurasikirwa kwekuziva), kurapwa nefurosemide kunofanira kuwedzerwa.
Varwere vane tsika kana psychogenic nyota;kusagadzikana angina pectoris;metabolic dysregulation cardiac insufficiency;mhando IIB vascular hemophilia.Kunyanya kukoshesa kunofanira kubhadharwa kune njodzi yekuchengetedza mvura.Kudya kwemvura kunofanirwa kuderedzwa kusvika kudiki muhuwandu sezvinobvira uye huremu hunofanira kuongororwa nguva nenguva.Kana pane kuwedzera zvishoma nezvishoma kwehuremu hwemuviri uye sodium yeropa inoderera pasi pe130 mmol / L kana plasma osmolality inowira pasi pe270 mosm / kg, kunwa kwemvura kunofanira kuderedzwa zvakanyanya uye desmopressin inorega.Shandisa nekuchenjerera muvarwere vaduku zvikuru kana vakwegura;mune varwere vane zvimwe zvinetso zvinoda diuretic therapy yemvura uye / kana solubility kusaenzana;uye mune varwere vari panjodzi yekuwedzera intracranial pressure.Coagulation zvinhu uye nguva yekubuda ropa inofanira kuyerwa usati washandisa mushonga uyu;plasma concentrations yeVIII: C uye VWF: AG inowedzera zvakanyanya mushure mekutonga, asi hazvina kuitika kumisa kuwirirana pakati pemazinga eplasma yezvinhu izvi uye nguva yekubuda ropa pamberi uye mushure mekutonga.Naizvozvo kana zvichibvira, mhedzisiro ye desmopressin panguva yekubuda ropa mumunhu mumwe nemumwe anorwara inofanirwa kuongororwa nekuyedza.
Nguva dzekubuda ropa dzinofanira kuenzaniswa sezvinobvira, semuenzaniso, nenzira yeSimplate II.Mhedzisiro paPregnancy and Lactation Miedzo yekuberekesa mumakonzo netsuro inoitwa kanopfuura kazana muyero wemunhu wakaratidza kuti desmopressin haikuvadze embryo.Mumwe munzveri akashuma zviitiko zvitatu zvokukanganisika muvacheche vanoberekwa nevakadzi vane pamuviri vane uremic avo vakashandisa desmopressin panguva yavakazvitakura, asi mimwe mishumo yezviitiko zvinopfuura 120 yakaratidza kuti vacheche vanoberekwa nevakadzi vakashandisa desmopressin panguva yavakazvitakura vakanga vakakwana.
Mukuwedzera, chidzidzo chakanyorwa zvakanaka chakaratidza kuti hapana kuwedzera kwehuwandu hwekuberekwa kusina kunaka muvana makumi maviri nepfumbamwe vakaberekwa nevakadzi vane pamuviri vakashandisa desmopressin panguva yose yekuzvitakura.Ongororo yemukaka wemukaka kubva kuvakadzi vanoyamwisa vakarapwa nemishonga yakakura (300ug intranasal) yakaratidza kuti huwandu hwedesmopressin hwakapfuudzwa kumucheche hwaive hushoma pane huwandu hunodiwa kukanganisa diuresis uye hemostasis.
Kugadzirira: Mishonga inorwisa-kuzvimba inogona kuwedzera mhinduro yemurwere kune desmopressin pasina kuwedzera nguva yayo yekuita.Zvimwe zvinhu zvinozivikanwa kuburitsa antidiuretic mahomoni, akadai se tricyclic antidepressants, chlorpromazine, uye carbamazepine, potentiate antidiuretic effect.Inowedzera njodzi yekuchengetwa kwemvura.
Nguva yekutumira: Jan-23-2024